CASP-9 (caspase 9, apoptosis-related cysteine peptidase)

CASP - 9 ( caspase 9 , apoptosis - related cysteine peptidase )

Three mRNA isoforms have been identified in Homo sapiens. Caspase-9S, also classified as caspase-9b or caspase9beta, is a small variant of caspase-9 lacking exons 3-6, which contain the catalytic domain. Caspase-9S functions as an endogenous dominant-negative isoform of full-length caspase-9 by binding to the Apaf-1 protein thus hampering its binding and processing of the full-length procaspase...

CASP 8 ( Caspase 8 , Apoptosis - Related Cysteine Peptidase )

Review on CASP8, with data on DNA/RNA, on the protein encoded and where the gene is implicated.

CASP 1 ( caspase 1 , apoptosis - related cysteine peptidase ( interleukin 1 , beta , convertase ) )

Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9.

Patched (Ptc), the main receptor for Sonic Hedgehog, is a tumor suppressor. Ptc has been shown to be a dependence receptor, and as such triggers apoptosis in the absence of its ligand. This apoptosis induction occurs through the recruitment by the Ptc intracellular domain of a caspase-activating complex, which includes the adaptor proteins DRAL and TUCAN, and the apical caspase-9. We show here ...

Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells.

Cyclophosphamide (CPA), a widely used oxazaphosphorine anti-cancer prodrug, is inactive until it is metabolized by cytochrome P450 to yield phosphoramide mustard and acrolein, which alkylate DNA and proteins, respectively. Tumor cells transduced with the human cytochrome P450 gene CYP2B6 are greatly sensitized to CPA, however, the pathway of CPA-induced cell death is unknown. The present study ...